Profen resolution

Details Profen resolution Profen resolution

1992-01-21

1994-04-12

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

548572, 549 79, 549499, 558414, 560 17, 560 21, 560 22, 560 43, 560 52, 560 55, 560 56, 560 61, 560100, 560102, 560105, 562402, C07B 5700, C07D30702, C07C 6760

Patent

active

053027515

ABSTRACT:
A process is disclosed that is useful for separating the enantiomers of a racemic mixture of an aliphatic carboxylic acid having the formula ##STR1## where R.sub.1 is hydrogen or alkyl, R.sub.2, R.sub.3 and R.sub.4 are independently different and are hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, heteroaryl, substituted heteroaryl, haloalkyl, alkoxyalkyl, alkylthioalkyl, phenylalkyl, substituted phenylalkyl, heteroalkylalkyl, substituted heteroalkylalkyl or cycloalkylalkyl. The process comprises forming a conglomerate salt by reacting the racemic mixture with a base, the conglomerate salt being a mixture of the enantiomeric salts and having the following properties:

REFERENCES:
patent: 4723033 (1988-02-01), Erickson
patent: 4983765 (1991-01-01), Lukas et al.
patent: 4994604 (1991-02-01), Tung et al.
patent: 5015764 (1991-05-01), Manimaran et al.
Jaques et al., Enantiomers, Racemates and Resolutions, pp. 193-196, John Wiley and Sons, Inc., New York (1981).
Sheldon, Chemistry & Industry, Apr. 2, 1990, pp. 212-219.

Affiliated with

Also associated with

Rating

Profen resolution does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Profen resolution, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Profen resolution will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2099901