Products of coupling biological substances by covalent bonds

Details Products of coupling biological substances by covalent bonds Products of coupling biological substances by covalent bonds

1986-03-24

1990-05-15

Lilling, Herbert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530388, 530395, 530406, 530410, 536 27, 435 6, 436501, C08G 8300, C07K 110, C07H 2100, C12Q 168

Patent

active

049259210

ABSTRACT:
This process involves the use of benzoquinone as cross-linking agent in large excess compared with the substance to be activated. The activation reaction is realized in a homogeneous liquid medium. Said process making it possible for example to couple antibodies to enzymes for determining or detecting said antibodies.
The process can be used for the determination of antitetanic antibodies in human serum.

REFERENCES:
patent: 3322634 (1967-05-01), Fulthorpe
patent: 4193982 (1980-03-01), Avrameas et al.
patent: 4592998 (1986-06-01), Avrameas et al.
Immunochemistry, 1974, vol. 11, pp. 261-269, Lemieux et al.
Immunochemistry, 1977, vol. 14, pp. 767-774, Ternynck et al.
Ann. Immunol (Inst. Pasteur), 1976, 127 C, 197-208, Ternynck et al.
EMBO Journal, vol. 2, No. 10, pp. 1655-1663, 1983, Louvard et al.
Joel W. Goodman, PhD, & An-Chuan Wang, Phd, "Basic & Clinical Immunology", second edition, pp. 23-24, Immunoglobulins: Structure & Diversity, Lange Medical Publications, Los Altos, California.
Brandt, J. et al, Biochim. Biophys. Acta, vol. 386, 1975, pp. 196-202.
Morrison, M. et al., Archiv. Biochem. Biophys., vol. 134, 1969, pp. 515-523.

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