Products based on polymers or copolymers substituted by groups h

Details Products based on polymers or copolymers substituted by groups h Products based on polymers or copolymers substituted by groups h

1984-06-21

1986-02-04

Henderson, Christopher A.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

5253315, 5253331, 5253332, 5253336, 525376, 525377, 527312, C08F 830

Patent

active

045687250

ABSTRACT:
Product constituted by a polymer or a copolymer having in its chain substitutable groups to which are statistically fixed X and Y groups, in which X represents SO.sub.3 --R.sup.1, with R.sup.1 being a hydrogen atom or a physiologically acceptable metal, wherein the Y groups have the formula --SO.sub.2 --R.sup.2, in which R.sup.2 represents a radical derived from arginine or an arginine derivative, bonded by its amino function --NH-- to the radical --SO.sub.2 --.
The invention also relates to a process for preparing such a product and to a process of the separation and purification of thrombin.

REFERENCES:
patent: 2808405 (1957-10-01), Novak
patent: 3301848 (1967-01-01), Halleck
European Search Report of French Application No. 83 10 773.
European Search Report of Application No. EP 80 40 1053.
Chemical Abstracts (1972), vol. 77, No. 18, "Polymeric Stabilizers of Aging", G. F. Bebikh et al., p. 21.
Boisson et al., Abstract to 11th Annual Meeting of the Society for Biomaterials, San Diego, California, 1985.
Okamoto et al., "Thrombin Inhibitors. 1. Ester Derivatives of N-(Arylsulfonyl)-L-Arginine, J. Med. Chem. 23:827 (1980).
Okamoto et al., "Thrombin Inhibitors 3. Carboxyl-Containing Amide Derivatives of N.sup.a -Substituted L-Arginine, J. Med. Chem. 23:1293 (1980).

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