Production process of S-phenyl-L-cysteine

Details Production process of S-phenyl-L-cysteine Production process of S-phenyl-L-cysteine

1996-07-10

1998-05-26

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435113, 435232, C12P 1304, C12P 1312, C12P 988

Patent

active

057563195

ABSTRACT:
S-phenyl-L-cysteine can be produced in a high yield by reacting thiophenol and L-serine under the action of tryptophan synthase at a pH in a range of from 9.0 to 10.5. Purification of S-phenyl-L-cysteine obtained by this enzyme reaction can be effectively achieved by adjusting the pH of a crystal-containing reaction mixture to a strongly acidic level of 1.5 or lower to dissolve crystals of S-phenyl-L-cysteine, adding activated carbon to the pH-adjusted mixture, maintaining the resultant mixture at a temperature of from 20.degree. to 60.degree. C. under aeration with an oxygen-containing gas, subjecting the thus-obtained mixture to filtration, raising the pH of the resulting filtrate back to a range of from 2.5 to 6.0 to precipitate crystals of S-phenyl-L-cysteine and then recovering the thus-precipitated crystals.

REFERENCES:
Database Biotechnology Abstracts Derwent, AN: 84-00221, XP002016581, JP-A-58146287 and JP-B-02054077, Aug. 1983, Abstracts.
Database WPI, Week 8451, Derwent Publications Ltd., London, GB; AN 84-316062, XP002016582 & JP-A-59198986, Nov. 1984, Abstract.
Chemical Abstracts, vol. 107, No. 15, Oct. 1987, Columbus, OH, US; Abstract No. 132635y, p. 584, Column 132626; XP002016579, Abstract & JP-A-62111694, May 1987.
Chemical Abstracts, vol. 107, No. 19, Nov. 1987, Columbus, OH, US; Abstract No. 174385; XP002016580; Abstract & JP-A-62143690, Jun. 1987.

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