Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Patent
1986-07-15
1987-09-01
Schain, Howard E.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
128334R, 1283355, 128DIG8, 514 21, 530356, C08H 106, C08L 8904, C08L 8906
Patent
active
046909737
ABSTRACT:
This invention concerns a production process of an antithrombogenic and antiadhesive material which can favorably be used as artificial blood vessels, artificial valves, grafting patches for cardiovascular organs, artificial heart catheters and so on. The gist of this invention is constructed substantially of subjecting glycidyltrialkylammonium halide such as glycidyltrimethylammonium chloride to the reaction with a material comprising pure collagen or collagen and other components like mucopolysaccharide in order to introduce a cationic quaternary functional group in collagen molecules of the material and then subjecting heparin to the ionic combination with the cationic functional group introduced. Meanwhile, in advance of the above chemical treatment, the material is prepared from dog's blood vessel by removing proteins except collagen, from cow's Achilles tendon by crushing into powder, from human amnion by rinsing in distilled water or from polyester knit tube by coating its inside with powdered collagen, for example.
REFERENCES:
patent: 4233360 (1980-11-01), Luck et al.
patent: 4238480 (1980-12-01), Sawyer
patent: 4280954 (1981-07-01), Yannas et al.
patent: 4451397 (1984-05-01), Huc et al.
Furuse Masayasu
Ito Hiraku
Kodaira Kazuhiko
Miyamoto Takeaki
Miyata Teruo
Koken Company Limited
Schain Howard E.
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