Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing a carotene nucleus
Reexamination Certificate
2006-11-07
2006-11-07
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing a carotene nucleus
C435S193000, C435S252300, C435S471000, C435S419000, C435S468000, C536S023200, C800S282000
Reexamination Certificate
active
07132257
ABSTRACT:
A method for the in vivo bioconversion of cyclic carotenes having a β-ionone ring to the corresponding aryl carotene is provided. Gram negative host cells expressing a heterologous, codon-optimized gene encoding a carotene desaturase are grown in the presence of a suitable cyclic carotene substrate to effect the production of aromatic carotenoids.
REFERENCES:
WO 03/093200 A-2 Cheng Qiong et al. Method for the synthesis of Aryl-carotenoids May 6, 2002.
Lee et al. Biosynthesis of stucturally Novel Carotenoids inEscherichia coli.May 2003. Chemistry and Biology, vol. 10, 453-462.
Novy et al. Overcoming the codon bias ofE. colifor enhanced protein expression Jun. 2001. InNovations news letter. vol. 12 article No. 1.
Krubasik P. et al. Acarotenogenic gene cluster from Brevibacterium linines with novel lycopene cyclase gene involvedin the synthesis of aromatic carotenoids. 2000.Mol. Gen.Genet. 263(3), 423-432.
G. Armstrong, 1999, Carotenoid Genetics and Biochemistry, In Comprehensive Natural Products Chemistry, Elsevier Press, vol. 2, pp. 321-352.
Krugel et al., Functional analysis of genes fromStreptomyces griseusinvolved in the synthesis of isorenieratene, a carotenoid with aromatic end groups, revealed a novel type of carotenoid desaturase, Biochimica et Biophysica Acta, 1439: pp. 57-64, 1999.
Krubasik and Sandmann, A carotenogenic gene cluster fromBrevibacterium linenswith novel lycopene cyclase genes involved in the synthesis of aromatic carotenoids, Mol. Gen. Genet 263: 423-432, 2000.
Viveiros et al.,Structural and functional analysis of the gene cluster encoding carotenoid biosynthesis inMycobacterium aurumA+, FEMS Microbiol Lett, 187: pp. 95-101, 2000.
Liaaen-Jensen et al., The Carotenoids of Photosynthetic Green Bacteria, ACTA Chem. Scand 18: 1703-1718, 1964.
Takaichi et al., New carotenoids from the thermophilic green sulfur bacteriumChlorobium tepidum: 1′,2′-dihydro-y-carotene, 1′-2′dihydrochlorobactene, and OH-chlorobactene glucoside ester, and the the carotenoid composition of different strains, Arch. Microbiol. 168: 270-276, 1997.
Eisen et al., The complete genome sequence ofChlorobium tepidumTLS, a photosynthetic, anaerobic, green-sulfur bacterium, PNAS USA, 99: 9509-9514, 2002.
Schumann et al., Activation and analysis of cryptic crt genes fro carotenoid biosynthesis fromStreptomyces griseus, Mol. Gen. Genet, vol. 252: pp. 658-666, 1996.
Lee et al., Biosynthesis of Structurally Novel Carotenoids inEscherichia coli, Chem Biol 10(5): pp. 453-462, 2003.
Kohl et al., The Pigment ofBrevibacterium Linens: Aromatic Carotenoids, Phytochemistry, vol. 22: pp. 207-213, 1983.
Cheng Qiong
Rouviere Pierre E.
Suh Wonchul
Tao Luan
E. I. du Pont de Nemours and Company
Gebreyesus Kagnew
Prouty Rebecca E.
LandOfFree
Production or aromatic carotenoids in gram negative bacteria does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Production or aromatic carotenoids in gram negative bacteria, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Production or aromatic carotenoids in gram negative bacteria will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3656991