Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2007-12-04
2007-12-04
Ramirez, Delia M. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C435S320100, C435S069100, C435S252300, C435S254200, C435S254230, C435S325000, C530S350000, C536S023100, C536S023200
Reexamination Certificate
active
11712877
ABSTRACT:
The invention concerns a method for the recombinant production or expression of eukaryotic alkaline phosphatase mutants in yeast cells wherein the specifically introduced mutations result in a reduction of the specific AP activity by at least a factor 1:100. The invention also concerns a method for inserting corresponding nucleic acid sequences into a vector for expression in methylotrophic yeast strains and it concerns corresponding vectors and host strains.
Geipel Frank
Hoelke Werner
Kirschbaum Thomas
Mueller Rainer
Thalhofer Johann-Peter
Amick Marilyn L.
Ramirez Delia M.
Roche Diagnostics Operations Inc.
Roche Diagnostics Operations Inc.
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