Production of vitamin K.sub.1 and vitamin K.sub.2

Details Production of vitamin K.sub.1 and vitamin K.sub.2 Production of vitamin K.sub.1 and vitamin K.sub.2

1979-02-27

1980-10-21

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

568790, 568766, C07C 4962, C07C 3914

Patent

active

042293561

ABSTRACT:
A process for producing hydro-precursors for vitamin K.sub.1 and vitamin K.sub.2 which comprises reacting (A) 2-methylhydronaphthoquinone-1,4 with (B) a compound selected from the group consisting of phytyl bromide, isophytyl bromide, geranyl bromide, farnesyl bromide, geranylgeranyl bromide and the corresponding chlorides in a reaction system which comprises an aqueous phase comprising an aqueous solution of an alkali and an oily phase comprising a hydrophobic organic solvent, in the presence of a salt comprising a quaternary ammonium ion or a tetraalkyl phosphonium ion represented by the formula (I) or formula (II): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each represent an alkyl or aralkyl group containing from 1 to 20 carbon atoms and the sum of the carbons in R.sub.1, R.sub.2, R.sub.3 and R.sub.4 groups is at least 12. The resultant hydro-precursor is oxidized to convert it into vitamin K.sub.1 or vitamin K.sub.2.

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