Production of viral vectors

Details Production of viral vectors Production of viral vectors

2001-09-21

2010-10-26

Marvich, Maria B (Department: 1633)

Chemistry: molecular biology and microbiology

Process of mutation, cell fusion, or genetic modification

Introduction of a polynucleotide molecule into or...

C435S456000, C435S325000, C424S199100, C424S233100, C424S093210

Reexamination Certificate

active

07820441

ABSTRACT:
The present invention relates to methods and compositions for the production of viral vectors. In particular, the present invention provides methods and compositions for faster, higher titer and higher purity production of viral vectors (e.g. adenoviral vectors). In some embodiments, the present invention provides gutted and helper viruses with identical or similar termini. In other embodiments, the present invention provides terminal protein linked adenoviral DNA. In certain embodiments, the present invention provides template extended adenoviral DNA.

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