Multicellular living organisms and unmodified parts thereof and – Method of making a transgenic nonhuman animal – Via microinjection of a nucleus into an embryo – egg cell – or...
Reexamination Certificate
2008-05-05
2010-10-26
Bertoglio, Valarie (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Method of making a transgenic nonhuman animal
Via microinjection of a nucleus into an embryo, egg cell, or...
C800S015000
Reexamination Certificate
active
07820878
ABSTRACT:
The present invention relates to a method of producing an ungulate having both copies of the IgM heavy chain (mu) rag-1 and/or rag-2 gene eliminated from its genome. Animals which have IgM, rag-1 and/or rag-2 eliminated from their genome are unable to conduct the gene rearrangements that are necessary to generate the antigen receptors of B- or T-lymphocytes, and therefore will not develop native B- or T-cells. Because they are unable to produce B- and T-lymphocytes, these IgM, rag-1, or rag-2 ungulates cannot reject human hematopoietic stem cell preparations, and B- and T-lymphocytes which develop therefrom. Therefore, the present invention also involves injecting into IgM, rag-1, and/or rag-2 deficient ungulates, in utero or shortly after birth, human B- and T-lymphocytes whose immune systems produce human immunoglobulin that can be processed for therapeutic uses in humans.
REFERENCES:
patent: 4797356 (1989-01-01), Brandt et al.
patent: 4847081 (1989-07-01), Rice
patent: 4873316 (1989-10-01), Meade et al.
patent: 4959317 (1990-09-01), Sauer
patent: 4994384 (1991-02-01), Prather et al.
patent: 5021244 (1991-06-01), Spaulding
patent: 5057420 (1991-10-01), Massey
patent: 5096822 (1992-03-01), Rosenkrans, Jr. et al.
patent: 5160312 (1992-11-01), Voelkel
patent: 5175384 (1992-12-01), Krimpenfort et al.
patent: 5213979 (1993-05-01), First et al.
patent: 5320952 (1994-06-01), Deutch et al.
patent: 5346990 (1994-09-01), Spaulding
patent: 5374544 (1994-12-01), Schwartz et al.
patent: 5434066 (1995-07-01), Bebee et al.
patent: 5434340 (1995-07-01), Krimpenfort et al.
patent: 5453366 (1995-09-01), Sims et al.
patent: 5464764 (1995-11-01), Capecchi et al.
patent: 5470560 (1995-11-01), Martin, Jr.
patent: 5482856 (1996-01-01), Fell, Jr. et al.
patent: 5487992 (1996-01-01), Capecchi et al.
patent: 5496720 (1996-03-01), Susko-Parrish et al.
patent: 5527674 (1996-06-01), Guerra et al.
patent: 5545806 (1996-08-01), Lonberg et al.
patent: 5545807 (1996-08-01), Surani et al.
patent: 5565350 (1996-10-01), Kmiec
patent: 5565362 (1996-10-01), Rosen
patent: 5569825 (1996-10-01), Lonberg et al.
patent: 5583016 (1996-12-01), Villeponteau et al.
patent: 5591669 (1997-01-01), Krimpenfort et al.
patent: 5612205 (1997-03-01), Kay et al.
patent: 5614396 (1997-03-01), Bradley et al.
patent: 5618686 (1997-04-01), Kojima et al.
patent: 5625126 (1997-04-01), Lonberg et al.
patent: 5627059 (1997-05-01), Capecchi et al.
patent: 5631153 (1997-05-01), Capecchi et al.
patent: 5633076 (1997-05-01), DeBoer et al.
patent: 5633425 (1997-05-01), Lonberg et al.
patent: 5639457 (1997-06-01), Brem et al.
patent: 5652373 (1997-07-01), Reisner
patent: 5654182 (1997-08-01), Wahl et al.
patent: 5660997 (1997-08-01), Spaulding
patent: 5661016 (1997-08-01), Lonberg et al.
patent: 5677177 (1997-10-01), Wahl et al.
patent: 5679523 (1997-10-01), Li et al.
patent: 5695977 (1997-12-01), Jurka
patent: 5698763 (1997-12-01), Weissmann et al.
patent: 5721367 (1998-02-01), Kay et al.
patent: 5733730 (1998-03-01), De Lange
patent: 5741957 (1998-04-01), Deboer et al.
patent: 5750172 (1998-05-01), Meade et al.
patent: 5756325 (1998-05-01), Kmiec
patent: 5763240 (1998-06-01), Zarling et al.
patent: 5770422 (1998-06-01), Collins
patent: 5770429 (1998-06-01), Lonberg et al.
patent: 5776744 (1998-07-01), Glazer et al.
patent: 5780009 (1998-07-01), Karatzas et al.
patent: 5780296 (1998-07-01), Holloman et al.
patent: 5789215 (1998-08-01), Berns et al.
patent: 5789650 (1998-08-01), Lonberg et al.
patent: 5789655 (1998-08-01), Prusiner et al.
patent: 5801030 (1998-09-01), McVey et al.
patent: 5814318 (1998-09-01), Lonberg et al.
patent: 5821117 (1998-10-01), Sandrin et al.
patent: 5827690 (1998-10-01), Meade et al.
patent: 5830698 (1998-11-01), Reff et al.
patent: 5837857 (1998-11-01), Villeponteau et al.
patent: 5843643 (1998-12-01), Ratner
patent: 5843754 (1998-12-01), Susko-Parrish et al.
patent: 5849991 (1998-12-01), d'Apice et al.
patent: 5849992 (1998-12-01), Meade et al.
patent: 5874299 (1999-02-01), Lonberg et al.
patent: 5876979 (1999-03-01), Andrews et al.
patent: 5877397 (1999-03-01), Lonberg et al.
patent: 5891698 (1999-04-01), Prieto et al.
patent: 5945577 (1999-08-01), Stice et al.
patent: 5952222 (1999-09-01), Rosenkrans, Jr. et al.
patent: 6011197 (2000-01-01), Strelchenko et al.
patent: 6023010 (2000-02-01), Krimpenfort et al.
patent: 6030833 (2000-02-01), Seebach et al.
patent: 6054632 (2000-04-01), Reid
patent: 6066719 (2000-05-01), Zapata
patent: 6074853 (2000-06-01), Pati et al.
patent: 6077710 (2000-06-01), Susko-Parrish et al.
patent: 6091001 (2000-07-01), Jakobovits et al.
patent: 6133503 (2000-10-01), Scheffler
patent: 6147276 (2000-11-01), Campbell et al.
patent: 6153428 (2000-11-01), Gustafsson et al.
patent: 6166288 (2000-12-01), Diamond et al.
patent: 6183993 (2001-02-01), Boyce et al.
patent: 6194202 (2001-02-01), Susko-Parrish et al.
patent: 6204061 (2001-03-01), Capecchi et al.
patent: 6204431 (2001-03-01), Prieto et al.
patent: 6252133 (2001-06-01), Campbell et al.
patent: 6258998 (2001-07-01), Damiani et al.
patent: 6271436 (2001-08-01), Piedrahita et al.
patent: 6300129 (2001-10-01), Lonberg et al.
patent: 6395958 (2002-05-01), Strelchenko et al.
patent: 6753457 (2004-06-01), Wangh et al.
patent: 7074983 (2006-07-01), Robl
patent: 2002/0001842 (2002-01-01), Chapman
patent: 2002/0012660 (2002-01-01), Colman et al.
patent: 2002/0069423 (2002-06-01), Good et al.
patent: 2002/0108132 (2002-08-01), Rapp
patent: 2002/0194635 (2002-12-01), Dunne et al.
patent: 2004/0068760 (2004-04-01), Robl et al.
patent: 2005/0097627 (2005-05-01), Robl
patent: 2006/0041945 (2006-02-01), Robl et al.
patent: 2006/0117394 (2006-06-01), Robl et al.
patent: 2006/0117395 (2006-06-01), Robl et al.
patent: 0773288 (1997-05-01), None
patent: 0546073 (1997-09-01), None
patent: 0843961 (1998-05-01), None
patent: 1106061 (2001-06-01), None
patent: WO 92/03918 (1992-03-01), None
patent: WO 93/10227 (1993-05-01), None
patent: WO 94/02602 (1994-02-01), None
patent: WO 95/23868 (1995-09-01), None
patent: WO 95/33828 (1995-12-01), None
patent: WO 96/33735 (1996-10-01), None
patent: WO 97/07668 (1997-03-01), None
patent: WO 97/07669 (1997-03-01), None
patent: WO 97/07671 (1997-03-01), None
patent: WO 97/13852 (1997-04-01), None
patent: WO 98/14593 (1998-04-01), None
patent: WO 98/24884 (1998-06-01), None
patent: WO 98/24893 (1998-06-01), None
patent: WO 98/30683 (1998-07-01), None
patent: WO 98/37183 (1998-08-01), None
patent: WO 98/39416 (1998-09-01), None
patent: WO 99/21415 (1999-05-01), None
patent: WO 99/60108 (1999-11-01), None
patent: WO 00/10383 (2000-03-01), None
patent: WO 00/42174 (2000-07-01), None
patent: WO 00/46251 (2000-08-01), None
patent: WO 00/51424 (2000-09-01), None
patent: WO 00/67568 (2000-11-01), None
patent: WO 00/67569 (2000-11-01), None
patent: WO 00/74477 (2000-12-01), None
patent: WO 01/23541 (2001-04-01), None
patent: WO 01/30992 (2001-05-01), None
patent: WO 01/35735 (2001-05-01), None
patent: WO 01/73107 (2001-10-01), None
patent: WO 02/12437 (2002-02-01), None
patent: WO 02/051997 (2002-07-01), None
patent: WO 02/070648 (2002-09-01), None
patent: WO 02/079416 (2002-10-01), None
patent: WO 2004/044156 (2004-05-01), None
Meirelles et al. Complete Replacement of the Mitochondrial Genotype in a Bos indicus Calf Reconstructed by Nuclear Transfer to a Bos taurus Oocyte. Genetics 2001, vol. 158, pp. 351-356.
Fehilly et al. Cytogenetic and Blood Group Studies of Sheep/Goat Chimaeras. J. Reproduct. Fertility. 1985, vol. 74, pp. 215-221.
Denning et al., “Gene Targeting in Primary Fetal Fibroblasts from Sheep and Pig,” Cloning and Stem Cells 3:221-231 (2001).
Ehrenstein et al., “Targeted Gene Disruption reveals a Role for Natural Secretory IgM in the Maturation of the Primary Immune Response,” Proc. Natl. Acad. Sci., USA 95:10089-10093 (1998).
Erlandsson et al., “Mice with an Inactivated joining chain Locus Have Perturbed IgM Secretion,” Eur. J. lmmunol. 28:2355-2365 (1998).
Goldman et al., “Enhanced Human Cell Engraftment in Mice Deficient in RAG2 and the Common Cytokine Receptor
Goldsby Richard A.
Kuroiwa Yoshimi
Osborne Barbara A.
Robl James M.
Bertoglio Valarie
Clark & Elbing LLP
Kyowa Hakko Kirin Co., Ltd.
LandOfFree
Production of ungulates, preferably bovines that produce... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Production of ungulates, preferably bovines that produce..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Production of ungulates, preferably bovines that produce... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4218679