Production of UGPPase

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase

Reexamination Certificate

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C435S006120, C435S200000, C435S174000, C435S069100, C435S320100, C435S325000, C436S023000

Reexamination Certificate

active

07338776

ABSTRACT:
A purified novel enzyme protein, UGPPase, which naturally occurs in animal cells, its productions of recombinant technology, an antibody to the enzyme protein, a method of carrying out ELISA for measurement of the amount of UGPPase in an analyte and a method for determination of UDPG in a sample. The one-way enzyme protein catalyses hydrolysis of UDP-glucose, the precursor molecule of glycogen, into glucose-1-phosphate (G1P) and uridine 5′-monophosphate (UMP).

REFERENCES:
Yagi et al. Cloning, expression and characterization of a mammalian Nudix hydrolase-like enzyme that cleaves the pyrophosphate bond of UDP-glucose. Biochem J. Mar. 1, 2003(Pt 2):409-15.
Database EMBL 'Online! EBI; Hypothetical protein, May 1, 1999 retrieved from EMBL Database accession No. 095848.
Bachorik P S et al: “The Purification and Properties of Detergent Solubilized Rat Liver Nucleotide Pyro Phosphatase” Journal of Biological Chemistry, vol. 247, No. 16, pp. 5071-5078.
Skidmore J R et al.: “Nucleotide Pyro Phosphatase EC-3.6.1.9 Activity of Rat Liver Plasma Membranes” Biochimica et Biophysica Acta, vol. 219, No. 1, 1970, pp. 93-103.
Schlisefeld L H et al: “The Purification and Properties of a Nucleotide Pyrophosphatase of Rat Liver Nuclei” The Journal of Biological Chemistry, vol. 240, No. 2, Feb. 1995, pp. 811-818.
Guranowski Andrzej: “Specific and nonspecific enzymes involved in the catabolism of mononucleoside and dinucleoside polyphosphates.” Pharmacology & Therapeutics, vol. 87, No. 2-3, Aug. 2000, pp. 117-139.
Bessman M J et al.: “The MutT proteins or Nudix hydrolases, a family of versatile, widely distributed, housecleaning enzymes” Journal of Biological Chemistry, American Society of Biological Chemists, vol. 271, No. 41, Oct. 11, 1996, pp. 25059-25062.
McLennman A G: “The Mut Motif Family of Nucleotide Phosphohydrolases in Man and Human Pathogens (Review)” International Journal of Molecular Medicine, vol. 4, No. 1, 1999, pp. 79-89.

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