Production of tumor angiogenesis factor by cell culture

Details Production of tumor angiogenesis factor by cell culture Production of tumor angiogenesis factor by cell culture

1979-04-25

1980-08-12

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435241, 435948, C12P 2100

Patent

active

042174120

ABSTRACT:
Process for the production of human TAF in vitro comprising growing the human medulloblastoma cell line TE-671 in agitated, liquid suspension of nutrient culture medium at about 35.degree.-38.degree. C. for a sufficient time to elaborate TAF and recovering the resulting TAF from the cells or cell product.

REFERENCES:
patent: 4059485 (1977-11-01), Tolbert
patent: 4059486 (1977-11-01), Tolbert
McAllister et al., Int. J. Cancer, 20, 206-212 (1977).
Folkman et al., Fundamental Aspects of Neoplasia, pp. 401-412, Springer-Verlag, New York, (1975).
Folkman et al., J. Exptl. Med., 133 278-288, (1971).
Phillips et al., Int. J. Cancer, 17, 549-558, (1976).
Hubler et al., Cancer, 38, 187-192, (1972).

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