Production of tumor angiogenesis factor by cell culture

Details Production of tumor angiogenesis factor by cell culture Production of tumor angiogenesis factor by cell culture

1978-12-29

1980-06-24

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

435 34, 435 29, 435240, 435948, C12P 100

Patent

active

042095875

ABSTRACT:
Process for the production of human TAF in vitro comprising growing the human liver adenocardinoma cell line SK-HEP-1 in agitated, liquid suspension of nutrient culture medium at about 35.degree.-38.degree. C. for a sufficient time to elaborate TAF and recovering the resulting TAF from the cells or cell product.

REFERENCES:
patent: 4059485 (1977-11-01), Tolbert
patent: 4059486 (1977-11-01), Tolbert
Fogh et al., J. Natl. Cancer Inst. 59, 221-225, (1977).
Folkman et al., Fundamental Aspects of Neoplasia, pp. 401-412, Springer-Verlag, New York, (1975).
Folkman et al., J. Exptl. Med., 133, 275-288, (1971).
Phillips et al., Int. J. Cancer 17, 549-558, (1976).
Hubler et al., Cancer 38, 187-192, (1976).

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