Adhesive bonding and miscellaneous chemical manufacture – Methods – Surface bonding and/or assembly therefor
Patent
1995-05-09
1997-10-28
Heitbrink, Jill L.
Adhesive bonding and miscellaneous chemical manufacture
Methods
Surface bonding and/or assembly therefor
156247, 156249, 156256, 156300, 156520, A61F 1302, B65C 102
Patent
active
056814135
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
A process for the continuous production and filling of plaster packaging with an active substance to be administered transdermally is known from DE-PS 32 04 582. In this process the active substance is applied to a carrier sheet, one portion at a time, at fixed intervals, is covered up by sections of metallic cover foil and then covered by an elastic skin adhesive sheet, using an interleaf sheet surrounding said sections of metallic cover foil, the skin adhesive sheet being adhesive on one side, namely that side opposite the interleaf sheet. After this, the portions of active substance are punched out, in the desired size, together with the surrounding sheet layers. This process involves relatively large technical resources and produces comparatively large amounts of surplus material.
A process for the continuous production of transdermal therapeutic plasters has also been suggested in which, to begin with, a laminate is produced by coating an intermediate carrier sheet with a preparation capable of flowing and containing active substance. This laminate is then trimmed to size, into strips of a given width, and, in further process steps, into sections of a determined length, containing active substance, the latter being applied, finally, at predetermined intervals, to a protective sheet covering them all over and, finally, being divided into individual plasters by separating the protective sheet transverse to the path of the belt, between the sections containing active substance. The process, it is true, solves very favourably the set task of obviating or minimizing the loss of active substance, as far as possible, but it is, however, comparatively complicated, owing to its many process steps.
DESCRIPTION OF THE INVENTION
It is the object of the invention under consideration, therefore, to transfer individual sections containing active substance, at high speed, very accurately, and without loss of the active substance, one after the other, at exactly predetermined intervals, from a first web to a second web overlapping the sections all round, in a technically simple and reliable manner. This task is solved, according to the invention, by a process in which a tape or web (1) and a second web (2) are moved forward by steps, with different phases of motion and stationary or inoperative phases and/or different step lengths and/or differing speeds and that, in the same appliance, in phase, in the same forward direction, during each inoperative or stationary phase of the webs (1,2), the subdivision of the layer containing active substance and, possibly, of one or more further layers, with the exception of the carrier layer, takes place at right angles to the direction of the web, into sections (7,8) containing active substance of a size suitable for the user, and their transfer to the second web, the carrier sheet (9) being removed, in preferably equal intervals, using a transfer device moving backwards and forwards in the direction of the web. Practical, additional embodiments of the invention are additionally described herein.
By applying the sections containing active substance from the first web to the second web during a stationary or inoperative phase of the webs, it is no longer necessary to exactly synchronize the speed of the webs in their phase of movement, and it will be possible to adjust the required forward feed lengths of the web exactly, in a simple manner, the distances between the sections containing active substance being easily varied in the required manner, by increasing the length of the forward feed length of the second web correspondingly by having different movement or stationary phases and/or lengths of cut and/or speeds of the two webs.
The advantage is the employment of a transfer device with a so-called dispenser edge, known, as such, from the application of labels to objects in labelling equipment, as they are known, for example, from DE-OS 15 11 873, DE-PS 25 55 910, DE-OS 32 33 546, DE-PS 36 18 542 and DE-GM 83 21 825. High production speeds can be
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Anhauser Dieter
Deurer Lothar
Grader Ludwig
Hille Thomas
Steinborn Peter
Heitbrink Jill L.
LTS Lohmann Therapie-Systeme GmbH & Co.
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