Production of tissue plasminogen activator factor

Details Production of tissue plasminogen activator factor Production of tissue plasminogen activator factor

1984-06-19

1987-04-28

Warren, Charles F.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435215, 435219, C12N 948, C12N 972, C12N 950

Patent

active

046614532

ABSTRACT:
A process for the production of a tissue plasminogen activator obtained from cultured rat prostate adenocarcinoma cells. The techniques described lead to enhanced production of the tissue plasminogen activator for markedly prolonged periods of time. The tissue plasminogen activator so produced may be used for the treatment of thrombosis.

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patent: 4328314 (1982-05-01), Horiguchi et al.
Strickland et al, "Purification and Properties of a Plasminogen Activator from Cultured Rat Prostate Adenocarcinoma", Biochemistry 22 p. 4444-9 (1983).
Rennie et al, "Plasminogen Activator in Prostatic Tumors of Nb Rats".
Biochinica et Biophysica Acta 632 p. 437-43 (1980).
Lechner et al, "Nutrition of Prostate Cells," Prog. Clin. Biol. Res., 37, p. 217-32 (1980) Chem. Abst. 93: 43358k.

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