Production of the lantibiotic cinnamycin with genes isolated...

Details Production of the lantibiotic cinnamycin with genes isolated... Production of the lantibiotic cinnamycin with genes isolated...

2007-01-23

2007-01-23

Weber, Jon (Department: 1653)

Chemistry: analytical and immunological testing

Process or composition for determination of physical state...

Corrosion resistance or power

C435S170000, C435S320100

Reexamination Certificate

active

10475970

ABSTRACT:
A 17 kb nucleic acid fragment, which confers production of the lantibiotic cinnamycin on non-producer Streptomycete strains, has been isolated fromStreptomyces cinnamoneus cinnamoneusDSM 40005 and characterized. Also provided are variants of the 17 kb fragment including variants in which non-essential genes are deleted and variants in which the propeptide sequence of the cinnamycin structural gene is altered, for example replaced with the propeptide sequence of similar B-type lantibiotics. Also provided are vectors, host cells and methods of lantibiotic production using the nucleic acid of the invention, and libraries of variants.

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