Production of the E. coli LT-B enterotoxin subunit in S. typhi

Details Production of the E. coli LT-B enterotoxin subunit in S. typhi Production of the E. coli LT-B enterotoxin subunit in S. typhi

1988-06-29

1992-01-07

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4351723, 435 91, 4353201, 435879, 424 93, 424 92, 536 27, 935 12, 935 29, 935 72, 530403, C12N 121, C12N 1503, C07H 1512, C07K 1500

Patent

active

050791656

ABSTRACT:
Methods and compositions are provided for the cloning and expression of plasmids bearing genes coding for the non-toxic subunit of the heat-laible enterotoxin (LT-B) of E. coli. These plasmids may be cloned into stable avirulent strains of Salmonella typhi and used to make oral bivalent vaccines. Such vaccines may be used to prevent typhoid fever and cholera-like enterotoxin-induced diarrheal disease.

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