Production of tertiary amines by reductive amination

Details Production of tertiary amines by reductive amination Production of tertiary amines by reductive amination

2005-09-27

2005-09-27

Raymond, Richard L. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

06949642

ABSTRACT:
A process for the production of tertiary amines by reductive amination of carbonyl compounds with secondary amines in the presence of a water scavenger, preferably trifluoroacetic acid anhydride, is disclosed. This process has applications in the preparation of imidazole-containing benzodiazepines, which are inhibitors of farnesyl protein transferase.

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Black and DiCesare Investigations into the Mechanism of the Titanium Isopropoxide Catalyzed Reductive Amination Reaction Book of Abstracts, 213 ACS National Meeting, San Francisco, Apr. 13-17. CHED-580 American Chemical Society: Wasington DC (1997).
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Form PCT/ISA/220 (Apr. 2002); International Search Report of PCT/US02/11942, filed Apr. 12, 2002; mailed Dec. 23, 2002.

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