Production of taxol from the yew tree

Details Production of taxol from the yew tree Production of taxol from the yew tree

1992-11-03

1995-08-29

Geist, Gary L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

549510, A61K 5100, C07D30500

Patent

active

054458099

ABSTRACT:
Taxol and radiolabelled taxol are produced from sterilized Yew trees by contacting sterilized Yew tree stock with a reactor solution comprising a taxol precursor under a reducing environment. The reactor solution may also contain a reducing agent, an energy source, a buffer to maintain pH in the range of 6.0 to 8.0, and a steroid inhibitor. A radiolabelled precursor may be included in the reactor solution to produced radiolabelled taxol.

REFERENCES:
patent: Re34277 (1993-06-01), Denis et al.
patent: 4049683 (1977-09-01), Okamoto et al.
patent: 4206221 (1980-06-01), Miller et al.
patent: 4814470 (1989-03-01), Colin et al.
patent: 4857653 (1989-08-01), Colin et al.
patent: 4924011 (1990-05-01), Denis et al.
patent: 4942184 (1990-07-01), Haugwitz et al.
patent: 4960815 (1990-10-01), Moos
patent: 5019504 (1991-05-01), Christen et al.
patent: 5202448 (1993-04-01), Carver et al.
patent: 5232684 (1993-08-01), Blumberg et al.
patent: 5243045 (1993-09-01), Holton et al.
patent: 5312740 (1994-05-01), Saito et al.
M. C. Wani et al., "Journal of the American Chemical Society", vol. 93, No. 9, pp. 2325-2327, May 1971.
Parness et al., J. Cell. Biol., vol. 91 (Nov. 1981) pp. 478-487.
Chenu et al., Journal of Labelled Compounds and Radiopharmaceuticals, vol. 24, No. 10 (1987) "Synthesis of a [3H]-Labelled Derivative of the Microtubular POison Taxol", pp. 1245-1255.

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