Induced nuclear reactions: processes – systems – and elements – Nuclear transmutation – By neutron bombardment
Patent
1997-08-20
1999-01-19
Jordan, Charles T.
Induced nuclear reactions: processes, systems, and elements
Nuclear transmutation
By neutron bombardment
376189, G21G 100
Patent
active
058621938
ABSTRACT:
Methods for the production of radionuclides suitable for use in radiopharmaceuticals for diagnostic and therapeutic applications, and specifically, to the production of .sup.186 Re, .sup.188 Re and other radionuclides such as .sup.195m Pt and .sup.198 Au using an inorganic Szilard-Chalmers reaction. Thin-film and powdered .sup.185 or 187 Re.degree. metal targets, and .sup.185 or 187 Re oxide/metal oxide target compositions with rhenium in a lower, relatively reduced oxidation state are prepared. The thin-film rhenium targets are aged for at least about 24 hours and then irradiated with neutrons in the present of an oxidizing medium sufficient to form a product nuclide in the higher oxidized state of perrhenate, ReO.sub.4.sup.-. Significantly, the rate and/or extent of oxidation of target nuclides which do not react with a neutron is controlled. For example, oxidation of such non-bombarded target nuclides is minimized by irradiating under vacuum, controlling the amount of oxidizing agent present, cooling during irradiation, etc. The product nuclide is recovered by dissolving the perrhenate in a non-oxidizing solvent such as water or saline.
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W. Jia et al. "The Production of very High Specific Activity re-186 Using an Inorganic Szilard Chalmers Process" Abstr. No. 057, Abstract of Papers, 212th American Chemical Society National Meeting, Orlando Florida, Aug. 25-29, 1996.
Z. Zhang et al. "Production of 186Re in High Specific Activity for Radioimmunotherapeutic Use By The Szilard-Chalmers Reaction" Abstr. No. 058, Abstract of Papers, 212th American Chemical Society National Meeting, Orlando Florida, Aug. 25-29, 1996.
W Jia et al. "Progress Toward Enhanced Specific Activity Re-186 Using Inorganic Szilard-Chalmers Methods" Technetium & Renium In Chemistry and Nuclear Medicine 4, Proceedings of the fourth International Symposium on Technetium in Chemistry and Nuclear Medicine, Seminario Maggiore, Bressanone, Italy (Sep. 12-14, 1994) pp. 379-381.
P. Schubiger et al. "Production of 186Re With High Specific Activity by the Szilard-Chalmers Reaction" Technical University of Munich, Munich, Germany, 1995.
Ehrhardt Gary J.
Jia Wei
Jordan Charles T.
Lattig Matthew J.
The Curators of the University of Missouri
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