Production of streptococcal M protein

Details Production of streptococcal M protein Production of streptococcal M protein

1994-02-22

1998-11-24

Housel, James C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

435 693, 4352523, 530350, A61K 3909, C12P 2106, C07K 100

Patent

active

058403140

ABSTRACT:
Methods and compositions are provided for the cloning and expression of Streptococcus pyogenes M protein genes, and, in particular, types 5, 6 and 24 gene in single-cell host organisms. The streptococcal M protein produced by the recombinant DNA techniques described herein may be formulated for use as immunogens in vaccines to protect against S. pyogenes infections. The gene for the M protein may further be employed as a molecular probe for the accurate identification of streptococci in infected body tissues and fluids.

REFERENCES:
patent: 4284537 (1981-08-01), Beachey
Manjula et al, "Studies on Group A Streptococcal M-proteins: purification of type 5M-protein and comparison of its amino terminal sequence with two immunologically virulent M-proteins molecules," Journal of Immunol. vol. 124, pp. 261-267, 1980.
Berzofsky et al; Science 229:932-940, 1985.
Stern P.S. TIBTECH 9:163-168, 1991.
Beachey et al, J Immunol 136(6):2287-2292, 1986.
Dale et al, J Exp Med 158(5):1727-1732, 1983.
Fischetti V.A. Methods in Enzymology 235:286-294, 1994.
Van de Rijn et al, Infect Immun 32(1):86-91, 1981.
Kehoe MA, Vaccine 9(11):797-806, 1991.
Ish-Horowicz et al, "Rapid and efficient cosmid cloning" Nucleic Acids Research, vol. 9, No. 13, pp. 2989-2998, 1981.

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