Production of solid pharmaceutical depot forms

Details Production of solid pharmaceutical depot forms Production of solid pharmaceutical depot forms

1993-06-21

1996-02-13

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

5147725, 5147726, 514781, 424465, A61K 4732, A61K 920

Patent

active

054909902

ABSTRACT:
A process for the production of solid pharmaceutical depot forms by application of a reconstituted aqueous dispersion of a pharmaceutically acceptable binder to a core which contains active substance or by wet granulation of the pharmaceutical active substance with such a binder dispersion or by direct tableting of an active substance with the redispersible binder powder, wherein the binder has been obtained by emulsion polymerization and subsequent spray drying of the resulting aqueous dispersion with a water-soluble pharmaceutically acceptable spraying aid with a glass transition temperature of at least 60.degree. C. and with or without a pharmaceutically acceptable antiblocking agent.

REFERENCES:
patent: Re27107 (1971-03-01), Levesque
patent: 3784648 (1974-01-01), Bergmeister et al.
patent: 4540602 (1985-09-01), Motoyama et al.
patent: 4737357 (1988-04-01), Lehmann et al.
patent: 4859751 (1989-08-01), Schulce et al.
patent: 4892910 (1990-01-01), Klesse et al.
patent: 5017631 (1991-05-01), Rauch et al.
patent: 5025004 (1991-06-01), Wu et al.

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