Organic compounds -- part of the class 532-570 series – Organic compounds – Silicon containing
Patent
1999-11-22
2000-07-04
Shaver, Paul F.
Organic compounds -- part of the class 532-570 series
Organic compounds
Silicon containing
C07F 708
Patent
active
060841176
ABSTRACT:
Lithiated haloarenes, although useful as intermediates in the synthesis of various end products, can be hazardous to prepare since unstable, shock sensitive compounds can be formed during lithiation of haloarenes. To avoid this problem, a reaction of a polyhaloarene with a hydrocarbyl lithium compound is conducted in the presence of another reactant so that the lithiated haloarene, if formed at all, exists as a transitory intermediate in low concentration. In this way, transitory lithiated haloarene which may be, and presumably is, formed in the reaction is converted into a non-hazardous functionally-substituted haloarene essentially as soon as such lithiated haloarene is formed. Thus, an arene having a halogen atom of atomic number greater than 9 substituted on at least two non-adjacent carbon atoms is concurrently reacted with a non-fluoro halotrihydrocarbylsilane and a hydrocarbyl lithium compound, in proportions such that a haloarene having at least one trihydrocarbylsilyl ring substituent is formed.
REFERENCES:
patent: 3485863 (1969-12-01), Nutzel et al.
patent: 4171360 (1979-10-01), Hill
patent: 5359065 (1994-10-01), Krishnamurthy
patent: 5498739 (1996-03-01), Takeuchi et al.
patent: 5589500 (1996-12-01), Edwards et al.
patent: 5780473 (1998-07-01), Murugesan et al.
Kurata et al., "Tandem Reactions of N,N-Dialkylamides With Organolithium Compounds and Cyclopentadiene. A New Efficient Synthesis of Pentafulvenes", Tetrahedron Letters, Jun. 1993, vol. 34, No. 21, pp. 3445-3448.
Berris Bruce C.
Mathur Rajeev S.
Owens David W.
Albemarle Corporation
Pippenger Philip M.
Shaver Paul F.
LandOfFree
Production of silated haloarenes by selective silylation of poly does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Production of silated haloarenes by selective silylation of poly, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Production of silated haloarenes by selective silylation of poly will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1487876