Production of selenium-72 and arsenic-72

Chemistry of inorganic compounds – Treating mixture to obtain metal containing compound – Radioactive metal

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Details

423249, 423510, 423DIG7, 376158, C01G 5700, C01G 2800

Patent

active

054055890

ABSTRACT:
Methods and apparatus for producing selenium-72, separating it from its daughter isotope arsenic-72, and generating multiple portions of a solution containing arsenic-72 from a reusable parent substance comprised of selenium-72. The invention provides apparatus which can be located at a site where arsenic-72 is used, for purposes such as PET imaging, to produce arsenic-72 as needed, since the half-life of arsenic-72 is very short.

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Regin Weinreich et al., "Production of .sup.72 Se/.sup.72 As and .sup.73 Se by Medium Energy Protons, " J. of Labelled Compounds and Radiopharmaceuticals, pp. 146-147 (1990).
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S. H. Al-Kouraishi et al, "An Isotope Generator for .sup.72 As," Int. J. of Applied Radiation & Isotopes, vol. 29, pp. 607-609 (1978).
Daniela Basile et al., "Excitation Functions and Production of Arsenic Radioisotopes for Environmental Toxicology and Biomedical Purposes, " Int. J. of Applied Radiation & Isotopes, vol. 32, pp. 403-410 (1981).
Patrick M. Grant et al., "Medium-Energy Spallation Cross Sections, 1.RbBr Irradiation with 800-MeV Protons," Int. J. of Applied Radiation and Isotopes, vol. 33, pp. 415-417 (1982).
D. R. Phillips et al., "Chemistry and Concept for an automated Se-72/As-72 Generator," Los Alamos National Laboratory LA-UR-91-517, submitted to New Trends in Radiopharmaceutical Synthesis, Quality Assurance and Regulatory Control, Plenum Publishing Corporation, New York, 1991.
D. R. Phillips et al., "Electrolytic Separation of Selenium Isotopes from Proton Irradiated RbBr Targets," Applied Radiation Isotopes, vol. 38, No. 7, pp. 521-525.

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