Production of reprogrammed cells with restored potential

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C536S023100, C536S024500, C435S006120, C435S325000

Reexamination Certificate

active

07601699

ABSTRACT:
A method for treating cells and/or nuclear transfer units and/or stem cells in culture with such compounds, individually or in combinations, is described. The method results in a globally hypomethylated genome and a restoration of cell differentiation and/or developmental potential, or potentiality. In addition, a method for the in vitro production of reprogrammed cells which have had differentiation potential (totipotential, pluripotential, or multipotential) restored by demethylating the genome is described.

REFERENCES:
patent: 5460964 (1995-10-01), McGlave et al.
patent: 5486359 (1996-01-01), Caplan et al.
patent: 5635387 (1997-06-01), Fei et al.
patent: 5677136 (1997-10-01), Simmons et al.
patent: 5716827 (1998-02-01), Tsukamoto et al.
patent: 5736396 (1998-04-01), Bruder et al.
patent: 5750397 (1998-05-01), Tsukamoto et al.
patent: 5759793 (1998-06-01), Schwartz et al.
patent: 5811094 (1998-09-01), Caplan et al.
patent: 5827670 (1998-10-01), Masinovsky et al.
patent: 5827735 (1998-10-01), Young et al.
patent: 5827740 (1998-10-01), Pittenger
patent: 5837539 (1998-11-01), Caplan et al.
patent: WO 02/077275 (2002-10-01), None
patent: WO 2006/088867 (2006-08-01), None
patent: WO 2008/124133 (2008-10-01), None
Scherer et al., Approaches for the sequence-specific knockdown of mRNA, 2003, Nat. Biotechnol., 21(12), pp. 1457-1465.
Zhang et al., Targeted Gene Silencing by Small Interfering RNA-Based Knock-Down Technology, 2004, Current Pharmaceutical Biotechnology, vol. 5, p. 1-7.
Rowling et al., Retinoid Compounds Activated and Induce Hepatic Glycine N-Methyltransferase in Rats, 2001, The Journal of Nutrition, 131(7), pp. 1914-1917.
Simonsson et al., DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei, 2004, Nature Cell Biology, vol. 6, No. 10, 2004, pp. 984-990.
Leu et al., Double RNA Interference of DNMT3B and DNMT1 Enhances DNA Demethylation and Gene Reactivation, 2003, Cancer Research, 63, pp. 6110-6115.
Balaghi M, et al., DNA methylation in folate deficiency: use of CpG methylase. Biochem Biophys Res Commun. 1993;193:1184-1190.
Alonso-Aperte E, et al., Brain folates and DNA methylation in rats fed a choline deficient diet or treated with low doses of methotrexate. Int J Vitamin Nutr Res. 1996; 66: 232-236.
Jacob RA, et al., Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women. J Nutr 1998;128:12041212.
Rampersaud GC, et al., Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. Am J Clin Nutr. 2000;72: 998-1003.
Pufulete M, et al., Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study. Gastroenterology. 2003;124:1240-1248.
Fowler BM, et al., Hypomethylation in cervical tissue: is there a correlation with folate status? Cancer Epidemiol Biomarkers Prev. 1998;7:901-906.
Fang JY, et al., Relationship of plasma folic acid and status of DNA methylation in human gastric cancer. J Gastroenterol. 1997;32:171-175.
Friso S, et al., A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc NatlAcad Sci USA. 2002;99:5606-5611.
Cravo M, et al., DNA methylation as an intermediate in colorectal cancer: modulation by folic acid supplementation. Eur J Cancer Prev Nov. 1994, 3:473-479.
Kim YI, et al., Effects of folate supplementation on two provisional molecular markers of colon cancer: a prospective, randomized trial. Am J Gastroenterol. 2001;96:184-195.
Ingrosso D, et al., Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia. Lancet. 2003;361:1693-1699.
Duthie SJ, et al., Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells. Nutr Cancer. 2000;37:245-251.
Carlson LL, et al., Properties and localization of DNA methyltransferase in preimplantation mouse embryos: implications for genomic imprinting. Genes Dev. 1992; 6: 2536-2541.
Chen T, et al., Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b. Mol Cell Biol. 2003;23:5594-5605.
Lei H, et al., De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development. 1996;122:3195-3205.
Mayer W, et al., Demethylation of the zygotic paternal genome. Nature. 2000;403:501-502.
Okano M, et al., DNA methyltransferases Dmnt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell. 1999;99:247-257.
Panning B, et al., DNA hypomethylation can activate Xist expression and silence X-linked genes. Genes Dev. 1996;10:1991-2002.
Jackson M, et al., Severe global DNA hypomethylation blocks differentiation and induces histone hypereacetylation in embryonic stem cells. Mol Cell Biol. 2004;24:8862-8871.
Simonsson S, et al., DNA methylation is necessary for the epigenetic reprogramming of somatic cell nuclei. Nat Cell Bio. 2004;6:984-990.
Bird A., DNA methylation patterns and epigenetic memory. Genes Dev. 2002;16:6-21.
Li, E., Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet. 2002;3:662-673.
Reik W, et al., Epigenetic reprogramming in mammalian development. Science. 2001;293:1089-1093.
Rideout WM III, et al., Nuclear cloning and epigenetic reprogramming of the genome. Science. 2001;293:1093-1098.
Surani MA., Reprogramming of genome function through epigenetic inheritance. Nature. 2001;414:122-128.
Feinberg AP, et al., The history of cancer epigenetics. Nat Rev Cancer. 2004;4:143-153.
Goodell MA., Stem cell “plasticity”: befuddled by the muddle. Curr Opin Hematol. 2003;10:208-213.
Pomerantz J, et al., Nuclear reprogramming: a key to stem cell function in regenerative medicine. Nat Cell Biol. 2004;6:810-816.
Hsieh J, et al., Epigenetic control of neural stem cell fate. Curr Opin Genet Dev. 2004;14:461-469.
Dean W, et al., Epigenetic programming in early mammalian development and following SCNT. Semin Cell Dev Biol. 2003;14:93-100.
Jouneau A, et al., Reprogramming in nuclear transfer. Curr Opin Genet Dev. 2003;13:486-491.
Kang YK, et al., Reprogramming DNA methylation in the preimplantation stage: pepping with Dolly's eyes. Curr Opin Cell Biol. 2003;15:290-295.
Hochedlinger K, et al.., Nuclear transplantation, embryonic stem cells and the potential for cell therapy. Hematol J. 2004;S114-S117.
Santos F, et al., Dynamic reprogramming of DNA methylation in the early mouse embryo. Dev Biol. 2002;241:172-182.
Lane N, et al., Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse. Genesis. 2003;35:88-93.
Adenot, PG, et al., Differential H4 acetylation of paternal and maternal chromatin precedes DNA replication and differential transcriptional activity in pronuclei of 1-cell mouse embryos. Development. 1997;124:4615-4625.
Lepikhov K, et al., Differential dynamics of histone H3 methylation at positions K4 and K9 in the mouse zygote. BMC Dev Biol. 2004;4:12-16.
Erhardt S, et al., Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development. 2003;130:4235-4248.
Santos F, et al., Dynamic chromatin modifications characterize the first cell cyde in mouse embryos. Dev Biol. 2005;280:225-236.
Monk M, et al., Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development. 1987;99:371-382.
Howlett SK, et al., Methylation levels of maternal and paternal genomes during preimplantation development. Development. 1991;113:119-127.
Bestor TH., The DNA methyltransferases of mammals. Hum Mol Genet. 2000;9:2395-2402.
Howell CY, et al., Genomic imprinting disrupted by a maternal effect mutation in the Dnmtl gene. Cell. 2001;104:829-838.
Fujimori T, et al., Analysis of cell lineage in two- and four- cell mouse embryos. Development. 2003;130:5113-

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