Production of recombinant AAV using adenovirus comprising...

Details Production of recombinant AAV using adenovirus comprising... Production of recombinant AAV using adenovirus comprising...

2006-10-03

2006-10-03

Nguyen, Dave Trong (Department: 1633)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S455000, C435S456000, C435S320100, C435S091410, C435S091420, C424S093200, C424S093210, C424S199100

Reexamination Certificate

active

07115391

ABSTRACT:
This invention relates to novel adenoviruses useful in the production of high titers of recombinant adeno-associated virus (rAAV) comprising a foreign DNA insert and methods of making these adenoviruses. The adenovirus comprises the AAV rep gene in which the p5 promoter is replaced by a minimal promoter or by no promoter. The invention also provides methods of producing high levels of rAAV as a substantially homogenous preparation and composition of rAAV.

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