Production of radioiodinated T.sub.3 and T.sub.4

Details Production of radioiodinated T.sub.3 and T.sub.4 Production of radioiodinated T.sub.3 and T.sub.4

1978-02-21

1980-03-11

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 232303, A61K 4300, G21H 502

Patent

active

041928580

ABSTRACT:
The chloramine T procedure is employed to provide radioiodinated T.sub.3 and radioiodinated T.sub.4 from T.sub.3 and T.sub.4, respectively, at specified pHs and mole ratios to provide for long shelf life. T.sub.3 is also radioiodinated to high specific activity radioiodinated T.sub.4, and purified after a specified waiting period to remove radioactive non-antigenic contaminants and thereby provide a long shelf life.

REFERENCES:
Weeke et al., Scand. J. Clin. Lab. Invest., 32, 357 (1973).
Hallaba et al., J. Nucl. Med., 15, 270 (1970).
Burger et al., Endocrinology, 94, 1189 (1974).
Kjeld et al., Clin. Chem. Acta., 61, 381 (1971).
Thurlow et al., Ann. Clin. Biochem., 13, 364 (1976).
Mayberry et al., J. Biol. Chem., 245, 697 (1970).
Dobas et al., J. Chem. Soc. Perkin A, (1972), 1189.
Gleason, J. Biol. Chem., 213, 837 (1955).
Latham et al., J. Biol. Chem., 251, 7388 (1976).
Jiang et al., J. Am. Chem. Soc., 97, 6551 (1975).

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