Production of radioiodinated T.sub.3 and T.sub.4

Details Production of radioiodinated T.sub.3 and T.sub.4 Production of radioiodinated T.sub.3 and T.sub.4

1979-04-25

1982-03-02

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 9900

Patent

active

043179215

ABSTRACT:
The chloramine T procedure is employed to provide radioiodinated T.sub.3 and radioiodinated T.sub.4 from T.sub.3 and T.sub.4, respectively, at specified pHs and mole ratios to provide for long shelf life. T.sub.3 is also radioiodinated to high specific activity radioiodinated T.sub.4, and purified after a specified waiting period to remove radioactive non-antigenic contaminants and thereby provide a long shelf life.

REFERENCES:
Weeke et al., Scand. J. Clin. Lab. Invest., 32, 357, (1973).
Berger et al., Endocrinology, 94, 1189, (1974).
Kjeld et al., Clin. Chem. Acta, 61, 381, (1971).
Thurlow et al., Ann. Clin. Acta. Biochem. 13, 364, (1976).
Gleason, J. Biol. Chem., 213, 837, (1955).

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