Production of (R)- and (S)-4-(1-aminoethyl) benzoic acid...

Details Production of (R)- and (S)-4-(1-aminoethyl) benzoic acid... Production of (R)- and (S)-4-(1-aminoethyl) benzoic acid...

2011-08-30

2011-08-30

Saucier, Sandy (Department: 1657)

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

C564S282000

Reexamination Certificate

active

08008062

ABSTRACT:
A method for preparing optically active methyl 4-(1-ammoniumethyl)benzoate sulfate by reacting racemic methyl 4-(1-aminoethyl)benzoate with an acylating agent in the presence of a lipase to give methyl 4-(1-aminoethyl)benzoate and subsequently precipitating methyl 4-(1-ammoniumethyl)benzoate sulfate by adding sulfuric acid.

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patent: WO-2005/105732 (2005-11-01), None
Dickins, R.S., et al., “Synthesis, Time-Resolved Luminescence, NMR Spectroscopy, Circular Dichroism and Circularly Polarised Luminescence Studies of Enantiopure Macrocyclic Lanthanide Tetraamide Complexes”, Chem. Eur. J., 1999, vol. 5, No. 3, pp. 1095-1105.
Kitagucki, H., et al, “Enzymatic Resolution of Racemic Amines: Crucial Role of the Solvent”, J. Amer. Chem. Soc., 1989, vol. 111, pp. 3094-3095.
Gotor, V., et al, “Enantioselective Acylation of Amino Alcohols by Porcine Pancreatic Lipase”, J. Chem. Soc. Chem. Commun., 1988, pp. 957-958.
Brieva, R., et al, “Enzymatic Synthesis of Amides with Two Chiral Centres”, J. Chem. Soc. Chem. Commun., 1990, pp. 1386-1387.

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