Production of purines via reductive formylation

Details Production of purines via reductive formylation Production of purines via reductive formylation

1995-06-26

1997-11-18

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Pteroyl per se or having -c-, wherein x is chalcogen, bonded...

544265, 544273, 544276, 544277, C07D47318, C07D47316, C07D47304, C07D47320

Patent

active

056889470

ABSTRACT:
In order to produce a purine of the general formula (I), ##STR1## in which R.sup.1 and R.sup.2 can be the same or different and denote H, OH, SH, NH.sub.2, N-(di)-alkyl, halogen, O-alkyl, S-alkyl, alkyl or aryl and alkyl represents an aliphatic residue with 1 to 4 carbon atoms and aryl represents a phenyl residue which is substituted if desired by CH.sub.3, OH, NH.sub.2 or halogen, from the corresponding 4-amino-5-nitrosopyrimidine of formula (II), ##STR2## in which R.sup.1 and R.sup.2 have the above-mentioned meaning, the compound of formula (II) is reductively formylated in a solvent at a temperature of 80.degree. to 220.degree. C. in the presence of formic acid and a catalyst based on a noble metal and the 4-amino-5-formylaminopyrimidine formed as an intermediate is cyclized.

REFERENCES:
patent: 4286093 (1981-08-01), Temple, Jr.
Shin Ozuka, Inorganica Chimica Acta 100, 141 (1985).

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