Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-05-14
2000-09-12
Park, Hankyel
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
530380, 435 702, 435 7021, 4351721, 4351722, 4351723, 435346, C12N 1509, C12N 512, A61K 3514, C12P 2104
Patent
active
061176524
ABSTRACT:
Methods for enhancing the production of tissue plasminogen activator (tPA) in cell culture are disclosed. The methods involve culturing tPA-producing cells in growth media supplemented with an alkanoic acid or salt thereof at a concentration which enhances tPA production. The most preferred methods utilize butyric acid or sodium butyrate at a concentration of between 0.1 mM and 10 mM.
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Alusuisse Holdings A.G.
Park Hankyel
Schneller John W.
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