Production of polyketides in bacteria and yeast

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound

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435 691, 435 697, 43525233, 43525421, 4353201, 435471, 435477, 435483, 435484, 435486, 435488, 536 232, 536 234, 536 237, C12P 726, C12N 1554, C12N 1562, C12N 1581

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060338830

ABSTRACT:
Hybrid and novel polyketide synthases and polyketides are produced by use of a multiple vector system. The combinatorial possibilities offered by placing the various catalytic activities of PKS systems on separate vectors permits the construction of improved libraries of PKS and polyketides. In addition, polyketides can be produced in hosts that ordinarily do not produce polyketides by supplying, along with an expression system for the desired PKS, an expression system for holo ACP synthase.

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