Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1993-02-01
1994-08-09
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
4352404, 43524045, 43524046, 43524048, 43524054, C12P 1718, C12N 500, C12N 502
Patent
active
053366050
ABSTRACT:
A process for the preparation of an adventive embryo of a plant belonging to the genus Podophyllum, comprising the steps of preparing cells of a plant belonging to the genus Podophyllum, incubating the cells in a sugar free medium or a medium containing up to 2% by weight sugar, and then incubating the cells in a medium containing more than 2% by weight of sugar to generate an adventive embryo; a process for the production of a podophyllotoxin compound comprising the steps of preparing an adventive embryo of a plant belonging to the genus Podophyllum, culturing the adventive embryo to generate an adventitious organ, culturing the adventitious organ to produce a podophyllotoxin compound, and recovering the podophyllotoxin compound; and a process for the production of a podophyllotoxin compound, comprising the steps of preparing de-differentiated cells or tissue of a plant belonging to the genus Podophyllum culturing the de-differentiated cells or tissue in a liquid medium to generate a differentiated organ, culturing the differentiated organ on a solid medium to produce a podophyllotoxin compound, and recovering the podophyllotoxin compound.
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Abstract JP 62-96088(A), "Production of AntiTumor Substance" (May 2, 1987) Kanebo Ltd.
Arumugan et al., Can. J. Bot., 68(3), 1990, pp. 487-491 (Biosis. Abstract 90000042).
van Uden et al., Plant Cell Reports, vol. 8, No. 3 (1989) pp. 165-168.
Gussman et al, Supplement to Plant Physiology, vol. 89, No. 4 (Apr. 1989) p. 11.
Heyenga et al, Plant Cell Reports, vol. 9 (1990) pp. 382-385.
Morita Eitaroh
Sakata Ko
Takezono Tetsuya
Dadio Susan M.
Nippon Oil Company Ltd.
Robinson Douglas W.
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