Production of pharmaceutical formulations for treatment of edema

Details Production of pharmaceutical formulations for treatment of edema Production of pharmaceutical formulations for treatment of edema

1997-09-02

2000-06-20

Levy, Neil S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424488, 426288, A61K 962

Patent

active

060775343

ABSTRACT:
The invention relates to a medicament containing a standardized dry extract of horse chestnut seeds which is active against various types of edema and diseases of the venous circulatory system and to a process for manufacturing this medicament. The dry seed extract is processed to the form of pellets which can be coated to obtain sustained release of the agent. In this way satisfying therapeutical blood levels of the triterpene glycosides as agent are achieved. The finished medicament according to the invention can best be provided as hard gelatin capsule or matrix tablet containing the extract pellets.

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HCAPLUS 1983: 443529 Bonati #77 3517 Switz. Mar. 1983.
Ditten M. et al, Untersuchung der Bioverfugbarkei von beta-Aescin nach oraler Verabreichung verschiedener Darreichungsformen vol. 51, No. 8, 1996, pp. 608-510, XP002084541.
"Rote Liste", 1997 Editio Cantor, Aulendorff/Wurtt, XP002084542, Nr. 83032, 83033.
Rote Liste (German Physician's Desk Reference) 1967: "Wenostasin".
Rote Liste 1974: "Venostasin Regard", No. 91001.
Monographie DAB 10, vol. 2 (1993): "Hippocastani extractum siccum normaturn".
Isaac Ghebre-Sellassie: "Pharmaceutical Pelletization Technolgy", NY (1989).
Med. Welt, Bd. 32, Nr. 51/52 (1981), S. 1953-1955.

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