Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1979-07-20
1981-07-14
Trousof, Natalie
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
C07D49912
Patent
active
042786002
ABSTRACT:
Trimethylsilyl or another easily hydrolyzed ester of 6-trimethylsilyloxycarbonylaminopenicillanic acid was prepared by bubbling dry carbon dioxide into ananhydrous solution of the corresponding 6-trimethylsilylaminopenicillanate and found to be a useful intermediate in the production of penicillins, e.g., amoxicillin and ampicillin, by its acylation in anhydrous media with the appropriate acid chloride or acid chloride hydrochloride.
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Johnson David A.
Sapino Chester
Silvestri Herbert H.
Walker Derek
Bristol-Myers Company
Clarke Vera C.
Taylor, Jr. Herbert W.
Trousof Natalie
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