Production of pellets composed of an ephedrine derivative

Details Production of pellets composed of an ephedrine derivative Production of pellets composed of an ephedrine derivative

1993-09-07

1995-09-26

Dawson, Robert A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424451, 424463, 424468, 424489, 424490, 424493, 424496, 424501, 264 43, 264 44, 264 46, 264117, A61K 954, B29B 908, B29B 916

Patent

active

054532809

ABSTRACT:
A process for producing pellets which are markedly spherical and have a particle size in the range from 0.1 to 4 mm and an apparent density above 0.5 g/cm.sup.3, and which are composed of 90-100% by weight of an ephedrine derivative and 0-10% by weight of a pharmaceutical aid, entails suspending ephedrine derivative powder with an average particle size of from 0.5 to 50 .mu.m at 0.degree.-90.degree. C. with stirring in a water-immiscible non solvent with a boiling point in the range from 60.degree. to 160.degree. C., adding 5-60% by weight, based on the ephedrine derivative, of an agglomerating liquid while continuing stirring, and, if there has been previous heating, cooling to from -5 to 25.degree. C. at 5-40K per hour, with the stirring speed being adjusted after the agglomeration of the powder particles to a value which is necessary for the required average particle size, and removing and drying the resulting pellets. A drug which contains the active ingredient in the form of such pellets, with or without slowing of release, is also described.

REFERENCES:
patent: 4205060 (1980-05-01), Monsimer et al.
patent: 4711782 (1987-12-01), Okada et al.
patent: 5160469 (1992-11-01), Moest
patent: 5292461 (1994-03-01), Juch et al.

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