Production of p-hydroxycephalexin

Details Production of p-hydroxycephalexin Production of p-hydroxycephalexin

1974-10-18

1976-10-12

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D50112

Patent

active

039857417

ABSTRACT:
Improved yields of 7-[D-.alpha.-amino-.alpha.-(4-hydroxy- and 3-chloro-4-hydroxy-phenyl)acetamido]-3-methyl-3-cephem-4-carboxylic acids are obtained by acylating 7-aminodesacetoxycephalosporanic acid with the mixed anhydride (from ethyl chloroformate) of the ring-substituted 2-phenylglycine when the latter's .alpha.-amino group has been blocked by reaction with a .beta.-keto compound such as methyl acetoacetate. Improved purification processes include the use of dimethylformamide and acetonitrile solvates and solvates and bis-anthraquinone-1,5-disulfonic acid salts.

REFERENCES:
patent: 3708478 (1973-01-01), Chapman et al.
patent: 3867380 (1975-02-01), Dunn et al.

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