Production of nonhygroscopic salts of 4-hydroxybutyric acid

Details Production of nonhygroscopic salts of 4-hydroxybutyric acid Production of nonhygroscopic salts of 4-hydroxybutyric acid

1981-07-13

1983-07-12

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

424317, C07C 5900

Patent

active

043932363

ABSTRACT:
A method for the production of nonhygroscopic magnesium and/or calcium salts of 4-hydroxybutyric acid. A member of the group consisting of magnesium hydroxide, magnesium oxide, magnesium carbonate, calcium hydroxide, calcium oxide and calcium carbonate is reacted with 4-hydroxybutyric acid and/or 4-butyrolactone in an aqueous solution. The solution is crystallized at a sufficiently low temperature for producing a solid nonhygroscopic salt. Waterfree calcium-4-hydroxybutyrate and waterfree as well as hydrated magnesium-4-hydroxybutyrate are added to pharmaceutically acceptable carrier or filler material for production of tranquilizing and/or sleeping drugs.

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