Production of neutralizing antibodies by polypeptide VP1 of ente

Details Production of neutralizing antibodies by polypeptide VP1 of ente Production of neutralizing antibodies by polypeptide VP1 of ente

1990-05-29

1993-07-27

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Lymphokine

424 89, A61K 3900

Patent

active

052308880

ABSTRACT:
The production of neutralizing antibodies for poliovirus, or other enteroviruses, are disclosed herein employing the capsid polypeptide VP1. Vaccines can be produced employing this polypeptide in place of killed or live attenuated virus, and the VP1 polypeptide can be employed in assays in place of whole virions. VP1 polypeptide can be produced by isolating it from live virion or can be produced by cloning cDNA sequences coding for this protein in recombinant cDNA vectors.

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