Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-01-03
2006-01-03
Canella, Karen A. (Department: 1642)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388100, C530S389100
Reexamination Certificate
active
06982318
ABSTRACT:
A class of motif-specific, context-independent antibodies that bind conserved signal transduction motifs, such as kinase consensus substrate motifs and protein-protein binding motifs, containing one or more modified amino acids, such as a phosphorylated amino acid, is provided. The antibodies bind a plurality of peptides or proteins that contain the modified motif. Context-independent antibodies specific for single modified residues, such as phosphothreonine, are also provided. Methods for producing and using such antibodies are provided.
REFERENCES:
patent: 5532167 (1996-07-01), Cantley et al.
patent: 5759787 (1998-06-01), Strulovici
patent: 6001580 (1999-12-01), Tani et al.
Miceli et al. J. Immunological Methods 167 :279-287 (1994).
Karin, Curr. Opin. Cell Biol. 6:415-424 (1994).
Lewis et al., Adv. Cancer Res. 74:49-139 (1998).
Crowley et al., Cell 77:841-852 (1994).
Fukunaga et al., EMBO 16(8):1921-1933 (1997).
Stukenberg et al., Curr. Biol. 7:338-348 (1997).
Burbelo et al., Curr. Biol. 5(2):95-96 (1995).
Yaffe et al., Cell 91:961-971 (1997).
Muslin et al., Cell 84:889-897 (1996).
Struhl, Genes & Dev. 12:599-606 (1998).
Imhof et al., Curr. Biol. 7:689-692 (1997).
Ross et al., Nature 294:654-656 (1981).
Kozma et al., Method. Enzymol. 201:28-43 (1991).
White et al., Method. Enzymol. 201:65-79 (1991).
Kamps, Method. Enzymol. 201:101-111 (1991).
Frackelton et al., Method. Enzymol. 201:79-92 (1991).
Wang, Method. Enzymol. 201:53-65 (1991).
Glenney, Method. Enzymol. 201:92-100 (1991).
Heffetz et al., Method. Enzymol. 201:44-53 (1991).
Czernik et al., Method. Enzymol. 201:264-283 (1991).
Czernik et al., Neuroprot. 6:56-61 (1995).
Patterson & Garrels, Cell Biology: A Laboratory Handbook 249-257 (1994), Academic Press.
Fields et al., Pept. Res. 4:95-101 (1991).
Dourtoglou et al., Synthesis 1984:572-574 (1984).
Knorr et al., Tetra. Let. 30:1927-1930 (1989).
Kearney et al., J. Immunol. 123:1548-1550 (1979).
Verhoeven, et al. Science 239:1534-1536 (1988).
Reichmann, et al., Nature (England) 332:323-327 (1988).
Huse, et al., Science 246:1275-1281 (1989).
Knorr, et al., Peptides 1988:37-39 (1989).
Hamaguchi, et al., Molecular & Cellular Biology 8:3035-3042 (1988).
Sigma 1998 Catalog pp. 1305 and 1309.
Upstate Biotechnology 1998 Catalog p. 17.
Zymed Laboratories 1996-1997 General Catalog p. 80.
Monoclonal Antibodies, Hybridomas: A New Dimension in Biological Analyses, Kennett et al. (eds.), Plenum Press (1980).
Antibodies: A Laboratory Manual, Harlow and Lane (eds.), Cold Spring Harbor Laboratory Press (1988).
Methods in Enzymology, vol. 201, Protein Phosphorylation, Part B Analysis of Protein Phosphorylation, Protein Kinase Inhibitors and Protein Phosphatases, Hunter and Sefton (eds.), Academic Press, Inc. (1991), pp. 3-547
Alessi, et al., FEBS Lett. 399:333-338 (1996).
Franke, et al. Cell 88:435-437 (1997).
Pap, et al., Biol. Chem. 273:19929-19932 (1998).
Datta, et al., Cell 91:231-241 (1997).
Brunet, et al., Cell, 96:857-868 (1999).
Cardone, et al., Science, 282:1318-1321 (1998).
Montminy, Annual Rev. Bochem. 66:807-822 (1997).
Songyang, et al., Current Biology 4:973-982 (1994).
Alessi, et al., EMBO J. 15:6541-6551 (1996).
Dalby, et al., J. Biol. Chem. 273:1496-1505 (1998).
Keranen, et al., Curr. Biol., 5:1395-1403 (1995).
Peng, et al., Science, 277:1501-1508 (1997).
Zha, et al., Cell 87:619-628 (1996).
Westendorf, PNAS, 91:714-718 (1994).
Rosenberg, et al., Journal of Biological Chemistry 268:4499-4503 (1993).
Kushima, et al., Journal of Molecular Neuroscience 8:19-27 (1997).
Yaffe, et al., Science 278:1957-1960 (1997).
Comb Michael J.
Tan Yi
Canella Karen A.
Cell Signaling Technology, Inc.
Cullem James Gregory
LandOfFree
Production of motif-specific and context-independent... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Production of motif-specific and context-independent..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Production of motif-specific and context-independent... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3597267