Production of monomeric human .gamma.-interferon

Details Production of monomeric human .gamma.-interferon Production of monomeric human .gamma.-interferon

1984-09-26

1987-08-11

Hazel, Blondel

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Lymphokines, e.g., interferons, interlukins, etc.

424 85, 435811, C07K 1526, A61K 4502

Patent

active

046862846

ABSTRACT:
Monomeric human .gamma.-interferon is efficiently produced by subjecting crude human .gamma.-interferon to gel filtration in the presence of a reducing sulfur compound and a protein-denaturing agent.

REFERENCES:
patent: 3981991 (1976-09-01), Stewart et al.
patent: 4100150 (1978-07-01), Cartwright
patent: 4278661 (1981-07-01), Knight, Jr.
patent: 4432895 (1984-02-01), Tarnowski
patent: 4476049 (1984-10-01), Kung
Giovanni Di Sabato; Purification and Initial Characterization of Rat Interleukin 2; Proceedings of the National Academy of Sciences; Jan. 1982, vol. 79, No. 1; pp. 3020-3023.

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