Production of monoclonal antibodies against bacterial adhesins

Details Production of monoclonal antibodies against bacterial adhesins Production of monoclonal antibodies against bacterial adhesins

1982-10-07

1984-04-17

Padgett, Benjamin R.

Chemistry: analytical and immunological testing

Involving production or treatment of antibody

Monoclonal antibody

424 9, 424 85, 424 87, 424177, 435 70, 435172, 435240, 435822, 435849, 435875, 260112R, A61K 3940, C12N 1500

Patent

active

044435495

ABSTRACT:
Monoclonal antibodies specific for surface antigens of bacteria which act as adhesins between prokaryotic and eukaryotic cells and, in particular, K-99 pili, and methods for production thereof are described. These monoclonal antibodies may be used for the prophylactic and therapeutic treatment of diseases induced by adhesin-bearing pathogens in animals and humans, and for the diagnostic identification of adhesin-bearing bacteria.

REFERENCES:
patent: 4298597 (1981-11-01), Acres et al.
patent: 4338298 (1982-07-01), Myers
patent: 4343792 (1982-08-01), Gouet et al.
Soderstrom, T. et al., Scandinavian J. Immunology, vol. 15, (1), p. 121 (1982).
Cisar, J. O. et al., J. Reticuloendothelial Society, vol. 28, pp. 73-79 (12-1980) "Use of Monoclonal Antibodies . . . ".
Cisar et al., J. Immunology, vol. 127, No. 4, pp. 1318-1322, (10-1981) "Detection and Localization of a lectinon Actinomyces . . . ".
Norky et al., Archives of Virology, vol. 71, pp. 1-11 (1982).
Feldner, Jr. et al., Nature, vol. 298, pp. 765-767 (1982).
Isaacson et al.; Infection & Immunity 21(2): 392-397 (1978).
Parry and Porter, Immunology 34: 41-49 (1978).
Hu et al., Science 216: 313-314 (Apr. 1982).

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