Production of molecular arrays

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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Reexamination Certificate

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10480702

ABSTRACT:
The subject invention pertains to a method for the production of an array of molecules immobilised on a substrate, comprising the deposition of the molecules from a micropipette containing them, onto the substrate, in a liquid environment, wherein the distance of the micropipette from the substrate is controlled in response to the ion current in the liquid. This method is particularly suitable for the deposition of biological molecules. The subject invention also pertains to an array of biological molecules deposited on a substrate.

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patent: 195 42 620 (1997-05-01), None
patent: WO 00/63736 (2000-10-01), None
MacBeath, G. and Schreiber, S.L. “Printing proteins as microarrays for high-throughput function determination”Science, 2000, pp. 1760-1763, vol. 289.
Müller, A.-D. et al. “Electrochemical pattern formation in a scanning near-field optical microscope”Appl. Phys. A., 1998, pp. S453-S456, vol. 66.
Piner, R.D. et al. “‘Dip-Pen’ nanolithography”Science, 1999, pp. 661-663, vol. 283.
Zhang, H. et al. “Electrochemical microprocess by scanning ion-conductance microscopy”J. Vac. Sci. Technol. B, 1999, pp. 269-272, vol. 17, No. 2.

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