Production of megakaryocytes by the use of human mesenchymal...

Details Production of megakaryocytes by the use of human mesenchymal... Production of megakaryocytes by the use of human mesenchymal...

2006-12-26

2006-12-26

Woitach, Joseph (Department: 1632)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C435S325000, C424S093100

Reexamination Certificate

active

07153500

ABSTRACT:
The present invention is directed to hematopoietic progenitor cells isolated from a tissue specimen, such as marrow cells or peripheral blood, and to the method of co-culturing isolated hematopoietic progenitor cells with human mesenchymal stem cells to induce megakaryocyte differentiation and platelet production. In addition, hematopoietic stem cells can be genetically engineered to carry genes of interest particularly for the expression of physiologically active proteins. In the presence of mesenchymal stem cells, the transduced cells carry the new genetic material and express gene products that can be used to modulate blood disorders.

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