Production of L-4-phenyl-2-aminobutanoic acid by transamination

Details Production of L-4-phenyl-2-aminobutanoic acid by transamination Production of L-4-phenyl-2-aminobutanoic acid by transamination

1984-08-23

1985-06-25

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435193, 435232, 435849, C12P 1304, C12N 910, C12N 988, C12R 119

Patent

active

045254540

ABSTRACT:
A process is described for producing L-4-phenyl-2-amino butanoic acid. The process comprises reacting 4-phenyl-2-oxobutanoic acid or an ester thereof with L-aspartic acid in the presence of transaminase enzyme to produce L-4-phenyl-2-aminobutanoic acid and oxaloacetate, and decarboxylating said oxaloacetate.

REFERENCES:
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patent: 3767528 (1973-10-01), Nagasaki et al.
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patent: 4304858 (1981-12-01), Wandrey et al.
Tosa et al., in Applied Microbiology, vol. 27, pp. 886-889, (1974).
Umbarger et al., in Annual Review of Microbiology, vol. 47, pp. 533-606, (1978).
Herbert, "Oxalacetic Carboxylase of Micrococcus lysodeikticus", Methods in Enzymology, vol. 1, pp. 753-757.

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