Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...
Patent
1993-09-07
1996-07-09
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing alpha or beta amino acid or substituted amino acid...
435115, 4351721, 435183, 4352528, C12P 1306, C12P 1308
Patent
active
055344216
ABSTRACT:
The present invention provides strains of Escherichia coli which have an isoleucine-tRNA synthetase with an increased Km and no negative feedback inhibition of isoleucine production. These strains are effective for the production of isoleucine in high amounts.
REFERENCES:
patent: 4278765 (1981-07-01), Debabov et al.
patent: 4388405 (1983-07-01), Sano et al.
Iaccarino et al., "Isoleucine Auxotrophy as a Consequence of a Mutationally Altered Isoleucyl-transfer Ribonucleic Acid Synthetase," J Bacteriology, vol. 185 No. 2, pp. 527-537, 1971.
Mizukami et al., "Essential Role of Aspartokinase in L-Threonine Production by Escherichia coli W Mutants," Agric Biol. Chem. vol. 50, No. 4, pp. 1015-1018, 1986.
Roth et al., "Histidine Regulatory Mutants in Salmonella typhimurium", J. Mol. Biol., vol. 22, pp. 325-334, 1966.
R. P. Lawther, et al, Proc. Natl. Acad. Sci. USA, vol. 78, pp. 922-925 (1981).
R. P. Lawther, et al, J. of Bacteriology, vol. 149, pp. 294-298 (1982).
Bachina Tatyana A.
Debabov Vladimir G.
Fedorovva Aaveilova O.
Khurges Evgeny M.
Livshits Vitaly A.
Ajinomoto Co. Inc.
Lilling Herbert J.
LandOfFree
Production of isoleucine by escherichia coli having isoleucine a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Production of isoleucine by escherichia coli having isoleucine a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Production of isoleucine by escherichia coli having isoleucine a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1866639