Production of immunogens by antigen conjugation to liposomes

Details Production of immunogens by antigen conjugation to liposomes Production of immunogens by antigen conjugation to liposomes

1983-08-03

1986-01-21

Wiseman, Thomas G.

Drug, bio-affecting and body treating compositions

Lymphokine

424 19, 424 78, 424785, 514 2, 514 6, 260112B, 260112R, 435 7, 435177, 435181, 436822, 436823, A61K 3900, A61K 3100, A61K 922, A61K 952, A61K 31682, A61K 4700, C07G 700, G01N 3354

Patent

active

045656967

ABSTRACT:
Enhanced immunogenicity is achieved by covalently linking immunogens to liposomes and injecting the membrane-bound-proteins into an appropriate vertebrate host. Methods and compositions are provided for producing antibodies.

REFERENCES:
Martin, Francis J. et al., J. Biol. Chem. (1982), v. 257, p. 286, "Irreversible Coupling of IgG Fragments to Preformed Vesicles". _
Shek, Pang et al., Immunology, v. 45, p. 349 (1981), "Immune Response Mediated by Liposome-Associated Protein Antigens".
Carlsson, Jan et al., Biochem. J. (1978), v. 173, pp. 723-737, "Protein Thiolation and Reversible Protein-Protein Conjugation".
McCormick, Patrick, Chem. Abstracts, v. 94, 61129m, "Coupling of BSA to Liposomes . . . ".
Freise, J. et al., Chem Abstracts, v. 94, 180599z.
Romanycheva et al., Chem Abstr., v. 84, No. 99405c, 1976, "Kinetics of Immunodepressive Action of Methotretate".
McCormick, Patrick Joseph, Diss. Abstr., No. 2064b, 1980, v. 41(b), p. 2064, "The Coupling of BSA to Liposomer Via Tolylene-2,4-Diisocyanate".

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