Production of imidazole derivatives and novel intermediates...

Details Production of imidazole derivatives and novel intermediates... Production of imidazole derivatives and novel intermediates...

2005-10-04

2005-10-04

Saeed, Kamal A. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

06951944

ABSTRACT:
An improvement in the production of imidazole derivatives including histamine H3agonist immepip and histamine H3antagonist VUF4929. Desired imidazole derivatives can be easily obtained in high yield by using novel intermediates represented by the general formula (I): (I) wherein R1is an amino-protecting group; R2and R3are each independently hydrogen, lower alkyl, or hydroxylated lower alkyl; R4is lower alkyl, halogenated lower alkyl, or substituted or unsubstituted phenyl; and A is C1-3alkylene

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Vollinga et al., “A New Potent and Selective Histamine H3Receptor Agnoist, 4-(1H-Imidazol-4-ylmethyl)piperidine”, Journal of Medicinal Chemistry (1994); 37: 332-333.
Harusawa et al., “An Efficient and Convenient Synthesis of 4-Vinylimidazoles Using Novel Homer-Wadsworth-Emmons (HWE) Reagent: Synthetic Studies Toward Novel Histamine H3-Ligands”, Synthesis (2002); No. 8: 1072-1078.

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