Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2006-10-31
2006-10-31
Wehbé, Anne Marie (Department: 1633)
Chemistry: molecular biology and microbiology
Vector, per se
C435S455000, C435S463000, C435S326000
Reexamination Certificate
active
07129084
ABSTRACT:
This invention relates to humanized antibodies and antibody preparations produced from transgenic non-human animals. The non-human animals are genetically engineered to contain one or more humanized immunoglobulin loci which are capable of undergoing gene rearrangement and gene conversion in the transgenic non-human animals to produce diversified humanized immunoglobulins. The present invention further relates to novel sequences, recombination vectors and transgenic vectors useful for making these transgenic animals. The humanized antibodies of the present invention have minimal immunogenicity to humans and are appropriate for use in the therapeutic treatment of human subjects.
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Buelow Jens-Ulrich
Buelow Roland
Platzer Josef
van Schooten Wim
Dreger, Esq. Ginger R.
Heller Ehrman LLP
Therapeutic Human Polyclonals, Inc.
Wehbe Anne Marie
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