Production of human recombinant collagen in the milk of transgen

Details Production of human recombinant collagen in the milk of transgen Production of human recombinant collagen in the milk of transgen

1995-06-07

1999-04-20

Stanton, Brian R.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

800 7, 800 25, C12N 1500

Patent

active

058958339

ABSTRACT:
Production of human procollagen or collagen in cells which ordinarily do not produce these molecules is effected by constructing expression systems compatible with mammary glands of non-human mammals. For example, expression systems can be microinjected into fertilized oocytes and reimplanted in foster mothers and carried to term in order to obtain transgenic non-human mammals capable of producing milk containing recombinant human procollagen or collagen. Human procollagen or collagen produced in this manner can be made of a single collagen type uncontaminated by other human or non-human collagens.

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